Het-PDB Navi2 (PDB: 6CYU)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
CE4	(2r)-2-[(R)-{[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-5-methylidene-5,6-dihydro -2h-1,3-thiazine-4-carboxylic acid				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 6CYU

Code :

6CYU PDBj RCSB PDB PDBe

Header :

hydrolase/antibiotic

Title :

Crystal structure of CTX-M-14 S70G/N106S/D240G beta-lactamase in complex with hydrolyzed cefotaxime

Release Data :

2018-10-10

Compound :

mol_id	molecule	chains
1	Beta-lactamase	A
	ec: 3.5.2.6 mutation: S70G, N106S, D240G

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli BL21(DE3) (taxid:469008)
	gene: blaCTX-M-14, beta-lactamase CTX-M-14, bla-CTX-M-14a, blaCTX-M-14a, blaCTX-M-14b, blaCTX-M-14c, blaCTX-M-27b, blatoho-3, blaUOE-2, CTX-M-14, AM333_26030, APT94_14605, BET08_34355, BJJ90_27545, BK334_27290, BMR21_24310, BMR35_25520, BMR49_25760, BXT93_06855, CA268_29135, CDL37_21060, CR538_26855, ETN48_p0088, pCT_085, pHK01_011

Authors :

Patel, M.P., Hu, L., Sankaran, B., Brown, C., Prasad, B.V.V., Palzkill, T.

Keywords :

Beta-lactamase CTX-M-14, hydrolase-hydrolase inhibitor complex, hydrolase-antibiotic complex

Exp. method :

X-RAY DIFFRACTION ( 1.820 Å )

Citation :

Synergistic effects of functionally distinct substitutions in beta-lactamase variants shed light on the evolution of bacterial drug resistance.

Patel, M.P.,Hu, L.,Brown, C.A. et al.
(2018) J. Biol. Chem. 293 : 17971 - 17984

Chain :

UniProt :

Q9L5C7 (Q9L5C7_ECOLX)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-lactam + H2O = a substituted beta-amino acid	3.5.2.6	ARBA:ARBA00001526, RuleBase:RU361140
a beta-lactam + H2O = a substituted beta-amino acid	-	ARBA:ARBA00001526, RuleBase:RU361140

PDB ID: 6CYU