Het-PDB Navi2 (PDB: 6CX0)

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Ligands
Code	Name		Style	Show	Link
CA	Calcium ion				PoSSuM
FJ7	(1s,3r)-1-(3-{[4-(2-fluorophenyl)piperazin-1-yl]methyl}-4-methoxyphenyl)-2,3,4,9-tetrahydro-1h-beta-carboline-3-carboxylic acid				PoSSuM

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Download interaction data: 6CX0

Code :

6CX0 PDBj RCSB PDB PDBe

Header :

membrane protein/inhibitor

Title :

Structure of AtTPC1 D376A

Release Data :

2018-09-19

Compound :

mol_id	molecule	chains	synonym
1	Two pore calcium channel protein 1	A	Calcium channel protein 1,AtCCH1,Fatty acid oxygenation up-regulated protein 2,Voltage-dependent calcium channel protein TPC1,AtTPC1
	mutation: D376A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Arabidopsis thaliana (taxid:3702)	Mouse-ear cress	Saccharomyces cerevisiae (taxid:4932)
	gene: TPC1, CCH1, FOU2, At4g03560, F9H3.19, T5L23.5 expression_system_strain: DSY5 expression_system_variant: -HIS expression_system_plasmid: p423Gal1

Authors :

Kintzer, A.F., Stroud, R.M.

Keywords :

Ion channel, Two-pore channel, TPC1, resting-state, closed, inactive, MEMBRANE PROTEIN, membrane protein-inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 3.501 Å )

Citation :

Structural basis for activation of voltage sensor domains in an ion channel TPC1.

Kintzer, A.F.,Green, E.M.,Dominik, P.K. et al.
(2018) Proc. Natl. Acad. Sci. U.S.A. 115 : E9095 - E9104

PDB ID: 6CX0