Brand  (β version)

PDB ID: 6CWY

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
FHJ Dimethyl (1s,2s,3r,4r)-1-[(1s)-2-(4-methylphenyl)-1-(phenylamino)ethyl]-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate PoSSuM
GOL Glycerol PoSSuM
MG Magnesium ion PoSSuM
SO4 Sulfate ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6CWY   PDBj   RCSB PDB   PDBe
Header : transferase/transferase inhibitor
Title : Crystal structure of SUMO E1 in complex with an allosteric inhibitor
Release Data : 2019-01-16
Compound :
mol_id molecule chains synonym
1 SUMO-activating enzyme subunit 1 C Ubiquitin-like 1-activating enzyme E1A
mol_id molecule chains synonym
2 SUMO-activating enzyme subunit 2 D Anthracycline-associated resistance ARX,Ubiquitin-like 1-activating enzyme E1B,Ubiquitin-like modifier-activating enzyme 2
ec: 2.3.2.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: SAE1, AOS1, SUA1, UBLE1A
expression_system_strain: BL21 DE3 Codon Plus
expression_system_vector_type: Plasmid
expression_system_plasmid: PET-15B
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: UBA2, SAE2, UBLE1B, HRIHFB2115
expression_system_strain: BL21 DE3 codon plus
expression_system_vector_type: plasmid
expression_system_plasmid: PET-28B
Authors : Lv, Z., Yuan, L., Atkison, J.H., Williams, K.M., Olsen, S.K.
Keywords : ROSSMANN-LIKE FOLD, UBIQUITIN-LIKE FOLD, UBIQUITIN ACTIVATING ENZYME, ACTIVITY, ATP BINDING, LIGASE ACTIVITY, ATP/MG BINDING, UBIQUITIN E2, LIGASE, TRANSFERASE, transferase-transferase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.4620 Å )
Citation :

Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme.

Lv, Z.,Yuan, L.,Atkison, J.H.  et al.
(2018)  Nat Commun  9 : 5145 - 5145

PubMed: 30514846
DOI: 10.1038/s41467-018-07015-1

Reaction

Chain : C
UniProt : Q9UBE0 (SAE1_HUMAN)
Reaction : -
Chain : D
UniProt : Q9UBT2 (SAE2_HUMAN)
Reaction : -