Brand  (β version)

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hetatm:

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centroid:
interaction residue:

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Ligands
Code Name Link
CL Chloride ion
ACT Acetate ion
F8Y (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one
GOL Glycerol
SO4 Sulfate ion
Code : 6CQH
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal Structure of the Human vaccinia-related kinase bound to a N-propynyl-N-ethyl-dihydropteridine inhibitor
Release Data : 2018-03-28
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase VRK1 A,B,C,D Vaccinia-related kinase 1
ec: 2.7.11.1
fragment: residues 3-364
mutation: K34A, K35A, E36A, E212A, K214A, E215A, E292A, K293A, K295A, K359A, K360A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: VRK1
expression_system_strain: BL21(DE3)
expression_system_variant: R3
expression_system_vector_type: plasmid
Authors : dos Reis, C.V., de Souza, G.P., Counago, R.M., Azevedo, A., Guimaraes, C., Mascarello, A., Gama, F., Ferreira, M., Massirer, K.B., Arruda, P., Edwards, A.M., Elkins, J.M., Structural Genomics Consortium (SGC)
Keywords : transferase, protein kinase domain, Structural Genomics, Structural Genomics Consortium, SGC, Transferase-Transferase Inhibitor Complex
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

Crystal Structure of the Human vaccinia-related kinase bound to a N-propynyl-N-ethyl-dihydropteridine inhibitor

dos Reis, C.V.,de Souza, G.P.,Counago, R.M.  et al.
To Be Published 

Chain : A, B, C, D
UniProt : Q99986 (VRK1_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.