Brand  (β version)

PDB ID: 6CQF

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Ligands
Code Name Style Show Link
F97 N-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3r)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1h-pyrazolo[4,3-C]pyridin-6-amine PoSSuM
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Structure summary

Code : 6CQF   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of HPK1 in complex an inhibitor G1858
Release Data : 2018-12-19
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase kinase kinase kinase 1 A HKP1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEKKK 1
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: MAP4K1, HPK1
expression_system_common: Fall armyworm
Authors : Wu, P., Lehoux, I., Mortara, K., Franke, Y., Chan, B.K., Wang, W.
Keywords : Protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.246 Å )
Citation :

Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer.

Wu, P.,Sneeringer, C.J.,Pitts, K.E.  et al.
(2019)  Structure  27 : 125 - 133.e4

PubMed: 30503777
DOI: 10.1016/j.str.2018.10.025

Reaction

Chain : A
UniProt : Q92918 (M4K1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:8824585
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:8824585
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:8824585
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