Brand  (β version)

PDB ID: 6CQ5

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Ligands
Code Name Style Show Link
F8S 2-amino-7-(1,1-dioxo-1lambda~6~-thian-4-yl)-5-oxo-5h-[1]benzopyrano[2,3-B]pyridine-3-carboxylic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 6CQ5   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : TBK1 in Complex with Sulfone Analog of Amlexanox
Release Data : 2018-12-05
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase TBK1 A NF-kappa-B-activating kinase,T2K,TANK-binding kinase 1
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: TBK1, NAK
expression_system_strain: SF9
expression_system_vector_type: baculovirus
expression_system_plasmid: pH7pFB
Authors : Beyett, T.S., Tesmer, J.J.G.
Keywords : TBK1, kinase, amlexanox, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 3.3540 Å )
Citation :

Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity.

Beyett, T.S.,Gan, X.,Reilly, S.M.  et al.
(2018)  Bioorg. Med. Chem.  26 : 5443 - 5461

PubMed: 30270002
DOI: 10.1016/j.bmc.2018.09.020

Reaction

Chain : A
UniProt : Q9UHD2 (TBK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:10783893, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:21138416, PubMed:21270402, PubMed:21464307, PubMed:21617041, PubMed:25636800, PubMed:29150432, PubMed:31530866, PubMed:31709703
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:10783893, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:21138416, PubMed:21270402, PubMed:21464307, PubMed:21617041, PubMed:25636800
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