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Ligands
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F8G S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (5r,10r)-7-hydroxy-10-methyl-2-oxo-1-oxaspiro[4.5]dec-6-ene-6-carbothioate (non-preferred name)
SO4 Sulfate ion
Non-standard Residues
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Glycosylation
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Code : 6CO9   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of Rhodococcus jostii RHA1 IpdAB COCHEA-COA complex
Release Data : 2018-03-28
Compound :
mol_id molecule chains
1 Probable CoA-transferase alpha subunit A
mol_id molecule chains
2 Probable CoA-transferase beta subunit B
Source :
mol_id organism_scientific expression_system
1 Rhodococcus jostii (strain RHA1)  (taxid:101510) Rhodococcus jostii RHA1  (taxid:101510)
strain: RHA1
gene: RHA1_ro04651
mol_id organism_scientific expression_system
2 Rhodococcus jostii  (taxid:101510) Rhodococcus jostii RHA1  (taxid:101510)
strain: RHA1
gene: RHA1_ro04650
Authors : Crowe, A.M., Workman, S.D., Watanabe, N., Worrall, L.J., Strynadka, N.C.J., Eltis, L.D.
Keywords : Cholesterol, Ring cleaving, virulence factor, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.6020 Å )
Citation :

IpdAB, a virulence factor inMycobacterium tuberculosis, is a cholesterol ring-cleaving hydrolase.

Crowe, A.M.,Workman, S.D.,Watanabe, N.  et al.
(2018)  Proc. Natl. Acad. Sci. U.S.A.  115 : E3378 - E3387

PubMed: 29581275
DOI: 10.1073/pnas.1717015115

Chain : A
UniProt : Q0S7P9 (IPDA_RHOJR)
Reaction: EC: Evidence:
Physiological Direction:
(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1- carboxyl-CoA + H2O = 6-methyl-3,7-dioxodecanedioyl-CoA - PubMed:29581275
left-to-right
Chain : B
UniProt : Q0S7Q0 (IPDB_RHOJR)
Reaction: EC: Evidence:
Physiological Direction:
(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1- carboxyl-CoA + H2O = 6-methyl-3,7-dioxodecanedioyl-CoA - PubMed:29581275
left-to-right