Brand  (β version)

color scheme of protein:


interaction residue:

chain: Hide other chain(s)

Code Name Link
CL Chloride ion
NA Sodium ion
PO4 Phosphate ion
Modified Residues
Code Name Link
F7P 1-[(3r)-3-hydroxy-2-methylbutan-2-yl]-L-tryptophan
F7S (4s)-5-hydroxy-N-methyl-L-leucine
F7V (2s,4e)-2-aminohex-4-enoic acid
MLE N-methylleucine
NIY Meta-nitro-tyrosine
Code : 6CN8
Title : High-resolution structure of ClpC1-NTD binding to Rufomycin-I
Release Data : 2019-06-05
Compound :
mol_id molecule chains
1 ATP-dependent Clp protease ATP-binding subunit ClpC1 A
other_details: N-terminal domain (UNP residues 1-145)
mol_id molecule chains
2 Rufomycin I B
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:562)
atcc: Rv3596c
gene: clpC1, Rv3596c, MTCY07H7B.26
expression_system_vector_type: plasmid
expression_system_plasmid: pET30a+
mol_id organism_scientific
2 Streptomyces atratus  (taxid:1893)
Authors : Abad-Zapatero, C., Wolf, N.W.
Keywords : Mycobacterium tuberculosis, rufomycin I, macrocyclic peptide, ClpC1-NTD, Chaperone, ATP-dependent protease, CHAPERONE-ANTIBIOTIC complex, ATPase AAA+, natural product
Exp. method : X-RAY DIFFRACTION ( 1.400 Å )
Citation :

High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads.

Wolf, N.M.,Lee, H.,Choules, M.P.  et al.
(2019)  Acs Infect Dis.  5 : 829 - 840

PubMed: 30990022
DOI: 10.1021/acsinfecdis.8b00276

Chain : A
UniProt : P9WPC9 (CLPC1_MYCTU)
Reaction : -