PDB ID: 6CN5
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Structure summary
Code : | 6CN5 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | SIGNALING PROTEIN | ||||||||||||
Title : | HUMAN RETENOID-RELATED ORPHAN RECEPTOR-GAMMA LIGAND- BINDING DOMAIN IN COMPLEX WITH INDOLE LIGAND CP9b IN INVERSE AGONIST CONFORMATION | ||||||||||||
Release Data : | 2018-09-05 | ||||||||||||
Compound : |
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Source : |
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Authors : | Kauppi, B., Vajdos, F. | ||||||||||||
Keywords : | ROR GAMMA, LIGAND-BINDING, NUCLEAR RECEPTOR, NON STEROIDAL, INDOLE, PFIZER, INVERSE AGONIST, SIGNALING PROTEIN | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.3000 Å ) | ||||||||||||
Citation : |
Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.
Schnute, M.E.,Wennerstal, M.,Alley, J.
et al.
PubMed: 30130103 |
Reaction
Chain : | A, B |
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UniProt : | P51449 (RORG_HUMAN) |
Reaction : | - |