Brand  (β version)

PDB ID: 6CMJ

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Ligands
Code Name Style Show Link
F6J 2-(2-methylpropyl)-4-(5-phenyl-1h-pyrrolo[2,3-B]pyridin-3-yl)benzoic acid PoSSuM
FMT Formic acid PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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SEP Phosphoserine
TPO Phosphothreonine
Glycosylation
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Structure summary

Code : 6CMJ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Human CAMKK2 with GSK650393
Release Data : 2018-04-04
Compound :
mol_id molecule chains synonym
1 Calcium/calmodulin-dependent protein kinase kinase 2 A,B CaMKK 2, Calcium/calmodulin-dependent protein kinase kinase beta, CaMKK beta
ec: 2.7.11.17
fragment: UNP residues 149-465
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CAMKK2, CAMKKB, KIAA0787
expression_system_vector_type: plasmid
expression_system_plasmid: pET24
Authors : Williams, S.P., Reid, R.A., Price, D.J., Drewry, D.H.
Keywords : kinase, signaling protein, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.4000 Å )
Citation :

An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model.

Price, D.J.,Drewry, D.H.,Schaller, L.T.  et al.
(2018)  Bioorg. Med. Chem. Lett.  28 : 1958 - 1963

PubMed: 29653895
DOI: 10.1016/j.bmcl.2018.03.034

Reaction

Chain : A, B
UniProt : Q96RR4 (KKCC2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.17 -
-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.17 -
-