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Ligands
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F5S (1ar,2z,4e,6e,14r,15ar)-9,11-dihydroxy-6-{[(4-methoxyphenyl)methoxy]imino}-14-methyl-1a,6,7,14,15,15a-hexahydro-12h-oxireno[E][2]benzoxacyclotetradecin-12-one
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Code : 6CJP   PDBj   RCSB PDB   PDBe
Header : CHAPERONE
Title : Candida albicans Hsp90 nucleotide binding domain in complex with radicicol
Release Data : 2019-01-30
Compound :
mol_id molecule chains
1 Heat shock protein 90 homolog A,B
Source :
mol_id organism_scientific organism_common expression_system
1 Candida albicans (strain SC5314 / ATCC MYA-2876)  (taxid:237561) Yeast Escherichia coli  (taxid:562)
strain: SC5314 / ATCC MYA-2876
gene: HSP90, CAALFM_C702030WA, CaJ7.0234, CaO19.13868, CaO19.6515
expression_system_strain: Rossetta 2
expression_system_plasmid: pET15-MHL
Authors : Nation, C., Pizarro, J.C.
Keywords : Hsp90. ATPase, CHAPERONE
Exp. method : X-RAY DIFFRACTION ( 2.6 Å )
Citation :

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.

Whitesell, L.,Robbins, N.,Huang, D.S.  et al.
(2019)  Nat Commun  10 : 402 - 402

PubMed: 30679438
DOI: 10.1038/s41467-018-08248-w

Chain : A, B
UniProt : P46598 (HSP90_CANAL)
Reaction : -