Brand  (β version)

PDB ID: 6CJF

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Ligands
Code Name Style Show Link
FMN Flavin mononucleotide PoSSuM
ORO Orotic acid PoSSuM
F54 2-[4-(2-chloro-6-methylpyridin-3-yl)phenyl]-6-fluoro-3-methylquinoline-4-carboxylic acid PoSSuM
ZWI 3-[decyl(dimethyl)ammonio]propane-1-sulfonate PoSSuM
Non-standard Residues
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Structure summary

Code : 6CJF   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Title : Human dihydroorotate dehydrogenase bound to 4-quinoline carboxylic acid inhibitor 43
Release Data : 2018-05-23
Compound :
mol_id molecule chains synonym
1 Dihydroorotate dehydrogenase (quinone), mitochondrial A,B DHOdehase,Dihydroorotate oxidase
ec: 1.3.5.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DHODH
Authors : Petrunak, E.M., Stuckey, J.A.
Keywords : Oxidoreductase, oxidoreductase inhibitor, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.630 Å )
Citation :

Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase.

Madak, J.T.,Cuthbertson, C.R.,Miyata, Y.  et al.
(2018)  J. Med. Chem.  61 : 5162 - 5186

PubMed: 29727569
DOI: 10.1021/acs.jmedchem.7b01862

Reaction

Chain : A, B
UniProt : Q02127 (PYRD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + a quinone = a quinol + orotate 1.3.5.2 PubMed:8925840
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