Het-PDB Navi2 (PDB: 6CJ1)

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Ligands
Code	Name	Link
EDO	1,2-ethanediol	PoSSuM
F2S	11-[(2r)-butan-2-yl]-2-({2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6h-pyrimido[4,5-B][1,4]benzodiazepin-6-one	PoSSuM
FND	11-[(2s)-butan-2-yl]-2-({2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6h-pyrimido[4,5-B][1,4]benzodiazepin-6-one	PoSSuM
NO3	Nitrate ion	PoSSuM

Non-standard Residues
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Download interaction data: 6CJ1

Code :

6CJ1 PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION/INHIBITOR

Title :

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG071

Release Data :

2018-08-29

Compound :

mol_id	molecule	chains	synonym
1	Bromodomain-containing protein 4	A	Protein HUNK1
	fragment: residues 44-166

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: BRD4, HUNK1

Authors :

Xu, X., Blacklow, S.C.

Keywords :

Kinase, Inhibitor, BRD4, TRANSCRIPTION, TRANSCRIPTION-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.530 Å )

Citation :

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.

Wang, J.,Erazo, T.,Ferguson, F.M. et al.
(2018) ACS Chem. Biol. 13 : 2438 - 2448

PDB ID: 6CJ1