Het-PDB Navi2 (PDB: 6CHZ)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
EDO	1,2-ethanediol				PoSSuM
F3D	4-[(2-{4-[(1e)-1-(1h-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 6CHZ

Code :

6CHZ PDBj RCSB PDB PDBe

Header :

nuclear protein/antagonist

Title :

Estrogen Receptor Alpha Y537S bound to antagonist H3B-9224.

Release Data :

2018-03-21

Compound :

mol_id	molecule	chains	synonym
1	Estrogen receptor	A	ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
	mutation: C381S, C417S, Y537S

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: ESR1, ESR, NR3A1

Authors :

Larsen, N.A.

Keywords :

Nuclear hormone receptor, antagonist, activating mutation, breast cancer, NUCLEAR PROTEIN, nuclear protein-antagonist complex

Exp. method :

X-RAY DIFFRACTION ( 1.68 Å )

Citation :

Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer.

Puyang, X.,Furman, C.,Zheng, G.Z. et al.
(2018) Cancer Discov 8 : 1176 - 1193

PDB ID: 6CHZ