Brand  (β version)

PDB ID: 6CGN

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Ligands
Code Name Style Show Link
DA 2'-deoxyadenosine-5'-monophosphate PoSSuM
PO4 Phosphate ion PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6CGN   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound (pH 7)
Release Data : 2018-05-09
Compound :
mol_id molecule chains
1 Ribonucleoside-diphosphate reductase A
ec: 1.17.4.1
fragment: \cf2 \cf0
Source :
mol_id organism_scientific expression_system
1 Bacillus subtilis  (taxid:1423) Escherichia coli  (taxid:469008)
gene: B4417_3413, CFD21_09965
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pE-SUMO
Authors : Maggiolo, A.O., Boal, A.K.
Keywords : ribonucleotide reductase, allostery, nucleotide metabolism, oxidoreductase, dAMP
Exp. method : X-RAY DIFFRACTION ( 2.2600 Å )
Citation :

An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.

Parker, M.J.,Maggiolo, A.O.,Thomas, W.C.  et al.
(2018)  Proc. Natl. Acad. Sci. U.S.A.  115 : E4594 - E4603

PubMed: 29712847
DOI: 10.1073/pnas.1800356115

Reaction

Chain : A
UniProt : A0A162Q3J9 (A0A162Q3J9_BACIU)
Reaction: EC: Evidence:
Physiological Direction:
[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'- diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'- diphosphate 1.17.4.1 ARBA:ARBA00000206, RuleBase:RU003410
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