Brand  (β version)

PDB ID: 6C73

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
CS Cesium ion PoSSuM
DMS Dimethyl sulfoxide PoSSuM
EDO 1,2-ethanediol PoSSuM
F9F 2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6C73   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Tryptophan synthase Q114A mutant (internal aldimine state) in complex with N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) with cesium ion bound in the metal coordination site
Release Data : 2019-01-23
Compound :
mol_id molecule chains
1 Tryptophan synthase alpha chain A
ec: 4.2.1.20
mol_id molecule chains
2 Tryptophan synthase beta chain B
ec: 4.2.1.20
mutation: Q114A
Source :
mol_id organism_scientific expression_system
1 Salmonella enterica subsp. enterica serovar Typhimurium  (taxid:90371) Escherichia coli  (taxid:562)
strain: LT2 / SGSC1412 / ATCC 700720
gene: trpA, STM1727
expression_system_strain: CB149
expression_system_vector_type: plasmid
expression_system_plasmid: PEBA-10
mol_id organism_scientific expression_system
2 Salmonella enterica subsp. enterica serovar Typhimurium  (taxid:90371) Escherichia coli  (taxid:562)
gene: trpB, STM1726
expression_system_strain: CB149
expression_system_vector_type: plasmid
expression_system_plasmid: PEBA-10
Authors : Hilario, E., Dunn, M.F., Mueller, L.J., Fan, L.
Keywords : F9F ligand, cesium ion, mutant beta-Q114A, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.6500 Å )
Citation :

Tryptophan synthase Q114A mutant (internal aldimine state) in complex with N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) with cesium ion bound in the metal coordination site.

Hilario, E.,Dunn, M.F.,Mueller, L.J.  et al.
To be Published 

Reaction

Chain : A
UniProt : P00929 (TRPA_SALTY)
Reaction: EC: Evidence:
Physiological Direction:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + L-tryptophan + H2O 4.2.1.20 HAMAP-Rule:MF_00131
-
Chain : B
UniProt : P0A2K1 (TRPB_SALTY)
Reaction: EC: Evidence:
Physiological Direction:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + L-tryptophan + H2O 4.2.1.20 -
-
Cofactor: Evidence: Note:
pyridoxal 5'-phosphate - -