Brand  (β version)

PDB ID: 6BY8

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Ligands
Code Name Style Show Link
DMS Dimethyl sulfoxide PoSSuM
EDO 1,2-ethanediol PoSSuM
FNV 4-methyl-1-{[(2r)-5-oxomorpholin-2-yl]methyl}-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-D]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1h-indole-2-carbonitrile PoSSuM
PG4 Tetraethylene glycol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 6BY8   PDBj   RCSB PDB   PDBe
Header : PROTEIN BINDING
Title : Menin in complex with MI-1482
Release Data : 2018-11-28
Compound :
mol_id molecule chains
1 Menin A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MEN1, SCG2
Authors : Borkin, T., Klossowski, S., Pollock, J., Linhares, B., Cierpicki, T., Grembecka, J.
Keywords : Protein binding, inhibitor
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.

Borkin, D.,Klossowski, S.,Pollock, J.  et al.
(2018)  J.Med.Chem.  61 : 4832 - 4850

PubMed: 29738674
DOI: 10.1021/acs.jmedchem.8b00071

Reaction

Chain : A
UniProt : O00255 (MEN1_HUMAN)
Reaction : -