Het-PDB Navi2 (PDB: 6BN7)

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Ligands
Code	Name		Style	Show	Link
RN3	Methyl {(6s)-4-(4-chlorophenyl)-2-[(8-{[({2-[(3s)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1h-isoindol-4-yl}oxy)acetyl]amino}octyl)carbamoyl]-3,9-dimethyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate				PoSSuM
ZN	Zinc ion				PoSSuM

Non-standard Residues
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Download interaction data: 6BN7

Code :

6BN7 PDBj RCSB PDB PDBe

Header :

LIGASE

Title :

Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET23 PROTAC.

Release Data :

2018-05-30

Compound :

mol_id	molecule	chains	synonym
1	DNA damage-binding protein 1	A	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe,DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe

mol_id	molecule	chains
2	Protein cereblon	B

mol_id	molecule	chains	synonym
3	Bromodomain-containing protein 4	C	Protein HUNK1
	mutation: T43M

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Trichoplusia ni (taxid:7111)
	gene: DDB1, XAP1 expression_system_common: Cabbage looper

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Trichoplusia ni (taxid:7111)
	gene: CRBN, AD-006 expression_system_common: Cabbage looper

mol_id	organism_scientific	organism_common	expression_system
3	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: BRD4, HUNK1

Authors :

Nowak, R.P., DeAngelo, S.L., Buckley, D., Bradner, J.E., Fischer, E.S.

Keywords :

PROTAC, degrader, E3 ligase, CRBN, LIGASE

Exp. method :

X-RAY DIFFRACTION ( 3.501 Å )

Citation :

Plasticity in binding confers selectivity in ligand-induced protein degradation.

Nowak, R.P.,DeAngelo, S.L.,Buckley, D. et al.
(2018) Nat. Chem. Biol. 14 : 706 - 714

PDB ID: 6BN7