Brand  (β version)

PDB ID: 6B7H

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CWY (1s,2s,4s,5r,6s)-2-amino-4-[(3-methoxybenzene-1-carbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid PoSSuM
Non-standard Residues
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Glycosylation
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NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 6B7H   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN/AGONIST
Title : Structure of mGluR3 with an agonist
Release Data : 2018-04-25
Compound :
mol_id molecule chains synonym
1 Metabotropic glutamate receptor 3 A mGluR3
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Unidentified baculovirus  (taxid:10469)
gene: GRM3, GPRC1C, MGLUR3
Authors : Monn, J.A., Clawson, D.K.
Keywords : mGluR3 Glutamate, MEMBRANE PROTEIN-AGONIST complex
Exp. method : X-RAY DIFFRACTION ( 2.8200 Å )
Citation :

Synthesis and Pharmacological Characterization of C4beta-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3Receptor Agonist.

Monn, J.A.,Henry, S.S.,Massey, S.M.  et al.
(2018)  J. Med. Chem.  61 : 2303 - 2328

PubMed: 29350927
DOI: 10.1021/acs.jmedchem.7b01481

Reaction

Chain : A
UniProt : Q14832 (GRM3_HUMAN)
Reaction : -