Brand  (β version)

PDB ID: 6B77

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Ligands
Code Name Style Show Link
CWV [3-(1-aminoisoquinolin-6-yl)phenyl]boronic acid PoSSuM
GOL Glycerol PoSSuM
IOD Iodide ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
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Structure summary

Code : 6B77   PDBj   RCSB PDB   PDBe
Header : BLOOD CLOTTING
Title : Structures of the two-chain human plasma factor XIIa co-crystallized with potent inhibitors
Release Data : 2018-03-21
Compound :
mol_id molecule chains synonym
1 Coagulation factor XII A Hageman factor,HAF
ec: 3.4.21.38
fragment: UNP residues 354-362
other_details: Activated Factor XIIa Part 1
mol_id molecule chains synonym
2 Coagulation factor XII B Hageman factor,HAF
ec: 3.4.21.38
fragment: UNP residues 373-615
other_details: Activated Factor XIIa Light Chain
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
Authors : Dementiev, A.A., Silva, A., Yee, C., Flavin, M.T., Partridge, J.R.
Keywords : Structural characterization of human plasma Factor XIIa in complexes with inhibitors, BLOOD CLOTTING
Exp. method : X-RAY DIFFRACTION ( 2.37 Å )
Citation :

Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors.

Dementiev, A.,Silva, A.,Yee, C.  et al.
(2018)  Blood Adv  2 : 549 - 558

PubMed: 29519898
DOI: 10.1182/bloodadvances.2018016337

Reaction

Chain : B
UniProt : P00748 (FA12_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa. 3.4.21.38 PubMed:2019570, PubMed:8427954
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