Het-PDB Navi2 (PDB: 6B77)

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hetatm:

information

centroid:

interaction residue:

chain: Hide other chain(s)

Ligands
Code	Name	Link
CWV	[3-(1-aminoisoquinolin-6-yl)phenyl]boronic acid	PoSSuM
GOL	Glycerol	PoSSuM
IOD	Iodide ion	PoSSuM
NAG	N-acetyl-D-glucosamine	PoSSuM
SO4	Sulfate ion	PoSSuM

Download interaction data: 6B77

Code :

Header :

BLOOD CLOTTING

Title :

Structures of the two-chain human plasma factor XIIa co-crystallized with potent inhibitors

Release Data :

2018-03-21

Compound :

mol_id	molecule	chains	synonym
1	Coagulation factor XII	A	Hageman factor,HAF
	ec: 3.4.21.38 fragment: UNP residues 354-362 other_details: Activated Factor XIIa Part 1

mol_id	molecule	chains	synonym
2	Coagulation factor XII	B	Hageman factor,HAF
	ec: 3.4.21.38 fragment: UNP residues 373-615 other_details: Activated Factor XIIa Light Chain

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human

Authors :

Dementiev, A.A., Silva, A., Yee, C., Flavin, M.T., Partridge, J.R.

Keywords :

Structural characterization of human plasma Factor XIIa in complexes with inhibitors, BLOOD CLOTTING

Exp. method :

X-RAY DIFFRACTION ( 2.37 Å )

Citation :

Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors.

Dementiev, A.,Silva, A.,Yee, C. et al.
(2018) Blood Adv 2 : 549 - 558

Chain :	B
UniProt :	P00748 (FA12_HUMAN)
Reaction :	Selective cleavage of Arg-\|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.

PDB ID: 6B77