Brand  (β version)

PDB ID: 6B73

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Ligands
Code Name Style Show Link
CVV N-[(5alpha,6beta)-17-(cyclopropylmethyl)-3-hydroxy-7,8-didehydro-4,5-epoxymorphinan-6-yl]-3-iodobenzamide PoSSuM
CLR Cholesterol PoSSuM
OLA Oleic acid PoSSuM
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Structure summary

Code : 6B73   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN/AGONIST
Title : Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor
Release Data : 2018-01-17
Compound :
mol_id molecule chains synonym
1 Soluble cytochrome b562, kappa-type opioid receptor A,B Cytochrome b-562,KOR-1
fragment: unp residues 23-128; unp residues 54-358
mutation: M29W, H124I, L51R, I135L
mol_id molecule chains
2 Nanobody C,D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Unidentified baculovirus  (taxid:10469)
gene: OPRK1, OPRK
mol_id organism_scientific expression_system
2 Lama glama  (taxid:9844) Lama glama  (taxid:9844)
Authors : Che, T., Majumdar, S., Zaidi, S.A., Kormos, C., McCorvy, J.D., Wang, S., Mosier, P.D., Uprety, R., Vardy, E., Krumm, B.E., Han, G.W., Lee, M.Y., Pardon, E., Steyaert, J., Huang, X.P., Strachan, R.T., Tribo, A.R., Pasternak, G.W., Carroll, I.F., Stevens, R.C., Cherezov, V., Katritch, V., Wacker, D., Roth, B.L.
Keywords : GPCR, opioid receptor, addiction, active state, nanobody, structure-function, morphinan, LCP, membrane protein, MEMBRANE PROTEIN-AGONIST complex
Exp. method : X-RAY DIFFRACTION ( 3.10 Å )
Citation :

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

Che, T.,Majumdar, S.,Zaidi, S.A.  et al.
(2018)  Cell  172 : 55 - 67.e15

PubMed: 29307491
DOI: 10.1016/j.cell.2017.12.011

Reaction

Chain : A, B
UniProt : P0ABE7 (C562_ECOLX)
Reaction : -
Chain : A, B
UniProt : P41145 (OPRK_HUMAN)
Reaction : -