Het-PDB Navi2 (PDB: 6B4L)

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Ligands
Code	Name		Style	Show	Link
CJY	3-{3-[(naphthalen-1-yl)oxy]propyl}-1h-indole-2-carboxylic acid				PoSSuM

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Download interaction data: 6B4L

Code :

6B4L PDBj RCSB PDB PDBe

Header :

signaling protein/inhibitor

Title :

Crystal structure of MCL-1 in complex with a BIM competitive inhibitor

Release Data :

2017-10-04

Compound :

mol_id	molecule	chains	synonym
1	Induced myeloid leukemia cell differentiation protein Mcl-1	A,B	Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT
	fragment: unp residues 174-326

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: MCL1, BCL2L3

Authors :

Judge, R.A., Souers, A.J.

Keywords :

MCL-1, signaling protein-inhibitor complex, SIGNALING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.2500 Å )

Citation :

Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.

Bruncko, M.,Wang, L.,Sheppard, G.S. et al.
(2015) J. Med. Chem. 58 : 2180 - 2194

PDB ID: 6B4L