PDB ID: 6B3W
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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ZN | Zinc ion | PoSSuM | |||
CJG | 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2h)-one | PoSSuM |
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Download interaction data: 6B3W
Structure summary
Code : | 6B3W PDBj RCSB PDB PDBe | ||||||||||||||||||||||||||||||||||||
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Header : | METAL BINDING PROTEIN | ||||||||||||||||||||||||||||||||||||
Title : | Structure of Hs/AcPRC2 in complex with 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one | ||||||||||||||||||||||||||||||||||||
Release Data : | 2017-12-27 | ||||||||||||||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Gajiwala, K.S., Brooun, A., Liu, W., Deng, Y., Stewart, A.E. | ||||||||||||||||||||||||||||||||||||
Keywords : | LYSINE METHYLTRANSFERASE, METAL BINDING PROTEIN | ||||||||||||||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 3.0500 Å ) | ||||||||||||||||||||||||||||||||||||
Citation : |
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).
Kung, P.P.,Bingham, P.,Brooun, A.
et al.
PubMed: 29211475 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | G1KPH4 (G1KPH4_ANOCA) | ||||||||
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Chain : | E, F |
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UniProt : | O75530 (EED_HUMAN) |
Reaction : | - |
Chain : | S, T |
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UniProt : | Q15022 (SUZ12_HUMAN) |
Reaction : | - |