Het-PDB Navi2 (PDB: 6B30)

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Ligands
Code	Name		Style	Show	Link
CFG	N-[(1r)-1-(4-methoxyphenyl)-2-oxo-2-{[4-(trimethylsilyl)phenyl]amino}ethyl]-N-methyl-3-oxo-2,3-dihydro-1,2-oxazole-5-carboxamide				PoSSuM

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Download interaction data: 6B30

Code :

6B30 PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN

Title :

Structure of RORgt in complex with a novel inverse agonist 1

Release Data :

2018-01-03

Compound :

mol_id	molecule	chains	synonym
1	Nuclear receptor ROR-gamma	A,B	Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: RORC, NR1F3, RORG, RZRG

Authors :

Skene, R.J., Hoffman, I.

Keywords :

Complex, inverse agonist, Nuclear Hormone Receptor, SIGNALING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.6900 Å )

Citation :

Discovery of orally efficacious ROR gamma t inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds.

Shirai, J.,Tomata, Y.,Kono, M. et al.
(2018) Bioorg. Med. Chem. 26 : 483 - 500

PDB ID: 6B30