Brand  (β version)

PDB ID: 6B2E

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Ligands
Code Name Style Show Link
AMP Adenosine monophosphate PoSSuM
CG7 5-{[6-chloro-5-(2'-hydroxy[1,1'-biphenyl]-4-yl)-1h-imidazo[4,5-B]pyridin-2-yl]oxy}-2-methylbenzoic acid PoSSuM
STU Staurosporine PoSSuM
GLC Alpha-D-glucopyranose PoSSuM
: Polysaccharide
Non-standard Residues
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SEP Phosphoserine
TPO Phosphothreonine
Glycosylation
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Modification
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Structure summary

Code : 6B2E   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of full length human AMPK (a2b2g1) in complex with a small molecule activator SC4.
Release Data : 2018-04-25
Compound :
mol_id molecule chains synonym
1 5'-AMP-activated protein kinase catalytic subunit alpha-2 A AMPK subunit alpha-2,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase
ec: 2.7.11.1,2.7.11.27,2.7.11.31
mol_id molecule chains synonym
2 5'-AMP-activated protein kinase subunit beta-2 B AMPK subunit beta-2
mol_id molecule chains synonym
3 5'-AMP-activated protein kinase subunit gamma-1 C AMPKg
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: PRKAA2, AMPK, AMPK2
expression_system_strain: Rosetta (DE3)
expression_system_plasmid: pETDuet-1
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: PRKAB2
expression_system_strain: Rosetta (DE3)
expression_system_plasmid: pRSFDuet-1
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: PRKAG1
expression_system_strain: Rosetta (DE3)
expression_system_plasmid: pETDuet-1
Authors : Ngoei, K.R.W., Langendorf, C.G., Ling, N.X.Y., Hoque, A., Johnson, S., Camerino, M.C., Walker, S.R., Bozikis, Y.E., Dite, T.A., Ovens, A.J., Smiles, W.J., Jacobs, R., Huang, H., Parker, M.W., Scott, J.W., Rider, M.H., Kemp, B.E., Foitzik, R.C., Baell, J.B., Oakhill, J.S.
Keywords : Phosphorylated, Active, Heterotrimer, Kinase., TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 3.80 Å )
Citation :

Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4.

Ngoei, K.R.W.,Langendorf, C.G.,Ling, N.X.Y.  et al.
(2018)  Cell Chem Biol  25 : 728 - 737.e9

PubMed: 29657085
DOI: 10.1016/j.chembiol.2018.03.008

Reaction

Chain : A
UniProt : P54646 (AAPK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:28552616, PubMed:32029622, PubMed:36732624, PubMed:37079666
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 UniProtKB:Q09137
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ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O- phospho-L-seryl-[acetyl-CoA carboxylase] - UniProtKB:Q09137
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ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] = ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3- methylglutaryl-coenzyme A reductase] 2.7.11.31 UniProtKB:Q09137
-
Chain : B
UniProt : O43741 (AAKB2_HUMAN)
Reaction : -
Chain : C
UniProt : P54619 (AAKG1_HUMAN)
Reaction : -