Brand  (β version)

PDB ID: 6B1Y

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Ligands
Code Name Style Show Link
CD7 (2s,5z)-1-formyl-5-imino-N'-[(3r)-1-(sulfooxy)pyrrolidine-3-carbonyl]piperidine-2-carbohydrazide PoSSuM
SO4 Sulfate ion PoSSuM
CL Chloride ion PoSSuM
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Structure summary

Code : 6B1Y   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE Inhibitor
Title : Crystal structure KPC-2 beta-lactamase complexed with WCK 5153 by co-crystallization
Release Data : 2018-08-01
Compound :
mol_id molecule chains synonym
1 Carbapenem-hydrolyzing beta-lactamase KPC A,B Carbapenem-hydrolyzing beta-lactamase KPC-1
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Klebsiella pneumoniae  (taxid:573) Escherichia coli  (taxid:562)
gene: bla, kpc, kpc1
Authors : van den Akker, F., Nguyen, N.Q.
Keywords : Inhibitor, complex, HYDROLASE, HYDROLASE-HYDROLASE Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.8000 Å )
Citation :

Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.

Papp-Wallace, K.M.,Nguyen, N.Q.,Jacobs, M.R.  et al.
(2018)  J. Med. Chem.  61 : 4067 - 4086

PubMed: 29627985
DOI: 10.1021/acs.jmedchem.8b00091

Reaction

Chain : A, B
UniProt : Q9F663 (BLKPC_KLEPN)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PubMed:11257029, PubMed:33257320
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