Brand  (β version)

PDB ID: 6B0F

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Ligands
Code Name Style Show Link
C6V Lsz102 PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6B0F   PDBj   RCSB PDB   PDBe
Header : HORMONE RECEPTOR
Title : ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH LSZ102
Release Data : 2018-04-04
Compound :
mol_id molecule chains synonym
1 Estrogen receptor A,B ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
fragment: residues 301-553
mutation: C381S, C417S, C530S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ESR1, ESR, NR3A1
Authors : Kirby, C.A., Baird, J.
Keywords : nuclear receptor, HORMONE RECEPTOR
Exp. method : X-RAY DIFFRACTION ( 2.86 Å )
Citation :

Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.

Tria, G.S.,Abrams, T.,Baird, J.  et al.
(2018)  J. Med. Chem.  61 : 2837 - 2864

PubMed: 29562737
DOI: 10.1021/acs.jmedchem.7b01682

Reaction

Chain : A, B
UniProt : P03372 (ESR1_HUMAN)
Reaction : -