Brand  (β version)

PDB ID: 6B06

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Ligands
Code Name Style Show Link
C6J 2-(2,2-diphosphonoethyl)-1-methylpyridin-1-ium PoSSuM
MG Magnesium ion PoSSuM
IPE 3-methylbut-3-enyl trihydrogen diphosphate PoSSuM
Non-standard Residues
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Structure summary

Code : 6B06   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of CfFPPS2, a lepidopteran type-II farnesyl diphosphate synthase, complexed with IPP and [2-(1-methylpyridin-2-yl)-1-phosphono-ethyl]phosphonic acid (inhibitor 1b)
Release Data : 2017-12-13
Compound :
mol_id molecule chains synonym
1 Farnesyl diphosphate synthase A,B,C CfFPPS2, type-II farnesyl diphosphate synthase
ec: 2.5.1.-
fragment: UNP residues 57-397
Source :
mol_id organism_scientific organism_common expression_system
1 Choristoneura fumiferana  (taxid:7141) Spruce budworm moth Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: Rosetta2 (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a
Authors : Picard, M.-E., Cusson, M., Shi, R.
Keywords : juvenile hormone, farnesyl diphosphate synthase, inhibitor design, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.6000 Å )
Citation :

Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana: Implications for inhibitor design.

Picard, M.E.,Nisole, A.,Beliveau, C.  et al.
(2017)  Insect Biochem. Mol. Biol.  92 : 84 - 92

PubMed: 29183817
DOI: 10.1016/j.ibmb.2017.11.011

Reaction

Chain : A, B, C
UniProt : Q1XAB1 (Q1XAB1_CHOFU)
Reaction : -
Cofactor: Evidence: Note:
Mg(2+) ECO:0000256 | ARBA:ARBA00001946
-