Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
C51 (2r)-N-(4-cyanophenyl)-2-[cis-4-(quinolin-4-yl)cyclohexyl]propanamide
Code : 6AZW
Header : oxidoreductase/oxidoreductase inhibitor
Title : IDO1/FXB-001116 crystal structure
Release Data : 2018-03-21
Compound :
mol_id molecule chains synonym
1 Indoleamine 2,3-dioxygenase 1 A,B IDO-1,Indoleamine-pyrrole 2,3-dioxygenase
ec: 1.13.11.52
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: IDO1, IDO, INDO
Authors : Lewis, H.A., Lammens, A., Steinbacher, S.
Keywords : IDO1/FXB-001116 crystal structure, oxidoreductase-oxidoreductase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.780 Å )
Citation :

Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.

Nelp, M.T.,Kates, P.A.,Hunt, J.T.  et al.
(2018)  Proc. Natl. Acad. Sci. U.S.A.  115 : 3249 - 3254

PubMed: 29531094
DOI: 10.1073/pnas.1719190115

Chain : A, B
UniProt : P14902 (I23O1_HUMAN)
Reaction : D-tryptophan + O(2) = N-formyl-D-kynurenine.
L-tryptophan + O(2) = N-formyl-L-kynurenine.