Brand  (β version)

PDB ID: 6AZJ

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C5V (1s,2s)-N-{4-[(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)methyl]phenyl}-2-(pyridin-3-yl)cyclopropane-1-carboxamide PoSSuM

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Non-standard Residues
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Glycosylation
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Structure summary

Code : 6AZJ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of human NAMPT in complex with NVP-LQN520
Release Data : 2018-09-12
Compound :
mol_id molecule chains synonym
1 Nicotinamide phosphoribosyltransferase A,B Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
ec: 2.4.2.12
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: NAMPT, PBEF, PBEF1
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET47b
Authors : Weihofen, W.A., Thigale, S.
Keywords : Transferase
Exp. method : X-RAY DIFFRACTION ( 2.53 Å )
Citation :

Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors

Palacios, D.,Meredith, E.,Kawanami, T.  et al.
To Be Published 

Reaction

Chain : A, B
UniProt : P43490 (NAMPT_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho- alpha-D-ribose 1-diphosphate + nicotinamide + H(+) 2.4.2.12 UniProtKB:Q99KQ4
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