Brand  (β version)

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Modified Residues
Code Name Link
011 7-aminoheptanoic acid
C4G N~5~-[N-(3-aminopropyl)carbamimidoyl]-L-ornithine
Code : 6AYN   PDBj   RCSB PDB   PDBe
Title : Structure of cetuximab with aminoheptanoic acid-linked N-(3-aminopropyl)-L-arginine meditope variant
Release Data : 2017-12-13
Compound :
mol_id molecule chains
1 Cetuximab Fab light chain A,C
mol_id molecule chains
2 Cetuximab Fab heavy chain B,D
mol_id molecule chains
3 Cyclic meditope E,F
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Unidentified  (taxid:32644)
gene: IGKC
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Unidentified  (taxid:32644)
mol_id organism_scientific
3 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Bzymek, K.P., Williams, J.C.
Keywords : antibody, anti-EGFR, immune system
Exp. method : X-RAY DIFFRACTION ( 2.480 Å )
Citation :

Meditope-Fab interaction: threading the hole.

Bzymek, K.P.,Ma, Y.,Avery, K.N.  et al.
(2017)  Acta Crystallogr F Struct Biol Commun  73 : 688 - 694

PubMed: 29199990
DOI: 10.1107/S2053230X17016272

Chain : A, C
UniProt : P01834 (IGKC_HUMAN)
Reaction : -
Chain : B, D
UniProt : S6B291 (No found in current UniProtKB/SwissProt)
Reaction : -