Brand  (β version)

PDB ID: 6AYD

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Ligands
Code Name Style Show Link
C2J N-[6-(4-hydroxyphenyl)-2h-indazol-3-yl]cyclopropanecarboxamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6AYD   PDBj   RCSB PDB   PDBe
Header : Transferase/Transferase Inhibitor
Title : Pim1 complexed with N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)cyclopropanecarboxamide
Release Data : 2017-12-27
Compound :
mol_id molecule chains
1 Serine/threonine-protein kinase pim-1 A
ec: 2.7.11.1
fragment: UNP residues 1-312
mutation: R250G
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PIM1
Authors : Shewchuk, L.M., Henley, Z.A.
Keywords : Kinase, Transferase-Transferase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 3.0 Å )
Citation :

From PIM1 to PI3K delta via GSK3 beta : Target Hopping through the Kinome.

Henley, Z.A.,Bax, B.D.,Inglesby, L.M.  et al.
(2017)  ACS Med Chem Lett  8 : 1093 - 1098

PubMed: 29057057
DOI: 10.1021/acsmedchemlett.7b00296

Reaction

Chain : A
UniProt : P11309 (PIM1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:31548394
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:15525646, PubMed:15657054, PubMed:15808862
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