Brand  (β version)

PDB ID: 6AXQ

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
DMS Dimethyl sulfoxide PoSSuM
C2Y Methyl 1h-indole-3-carboxylate PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6AXQ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE inhibitor
Title : CREBBP bromodomain in complex with Cpd6 (methyl 1H-indole-3-carboxylate)
Release Data : 2018-02-21
Compound :
mol_id molecule chains
1 CREB-binding protein A,B,C,D
ec: 2.3.1.48
fragment: bromodomain (UNP residues 1085-1196)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CREBBP, CBP
Authors : Murray, J.M., Jayaram, H.
Keywords : CREBBP, Bromodomain, TRANSFERASE-TRANSFERASE inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.3000 Å )
Citation :

A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors.

Bronner, S.M.,Murray, J.,Romero, F.A.  et al.
(2017)  J. Med. Chem.  60 : 10151 - 10171

PubMed: 29155580
DOI: 10.1021/acs.jmedchem.7b01372

Reaction

Chain : A, B, C, D
UniProt : Q92793 (CBP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L- lysyl-[histone] 2.3.1.48 PubMed:24616510
left-to-right
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] - PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:30540930, PubMed:35675826
left-to-right PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:28790157, PubMed:30540930, PubMed:35675826