Het-PDB Navi2 (PDB: 6AQ4)

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Data format:

Color scheme of protein:

Ligands
Code	Name	Link
CL	Chloride ion	PoSSuM
CQM	Citramalyl-CoA	PoSSuM
GOL	Glycerol	PoSSuM
MG	Magnesium ion	PoSSuM
PO4	Phosphate ion	PoSSuM
PYR	Pyruvic acid	PoSSuM

Non-standard Residues
Code	Name	Show
CSO	S-hydroxycysteine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 6AQ4

Code :

6AQ4 PDBj RCSB PDB PDBe

Header :

LYASE

Title :

CRYSTAL STRUCTURE OF PROTEIN CiTE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MAGNESIUM, PYRUVATE AND CITRAMALYL-COA

Release Data :

2018-08-01

Compound :

mol_id	molecule	chains
1	Citrate lyase subunit beta-like protein	A,B,C
	ec: 4.1.-.-

Source :

mol_id	organism_scientific	expression_system
1	Mycobacterium tuberculosis H37Rv (taxid:83332)	Escherichia coli K-12 (taxid:83333)
	gene: citE, Rv2498c

Authors :

Fedorov, A.A., Fedorov, E.V., Wang, H., Bonanno, J.B., Carvalho, L., Almo, S.C.

Keywords :

Mycobacterium tuberculosis, CitE, Citramalyl-CoA, TIM-barrel fold, trimer, LYASE

Exp. method :

X-RAY DIFFRACTION ( 1.825 Å )

Citation :

An essential bifunctional enzyme inMycobacterium tuberculosisfor itaconate dissimilation and leucine catabolism.

Wang, H.,Fedorov, A.A.,Fedorov, E.V. et al.
(2019) Proc.Natl.Acad.Sci.USA 116 : 15907 - 15913

Discovery of a novel stereospecific beta-hydroxyacyl-CoA lyase/thioesterase shared by three metabolic pathways in Mycobacterium tuberculosis

Wang, H.,Fedorov, A.A.,Fedorov, E.V. et al.
(2018) Biorxiv

Chain :

A, B, C

UniProt :

P9WPE1 (CITEL_MYCTU)

Cofactor:	Evidence:	Note:
Reaction :	-
Mg(2+)	-	Binds 1 Mg(2+) ion per subunit.

PDB ID: 6AQ4