Brand  (β version)

PDB ID: 6AJJ

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Ligands
Code Name Style Show Link
J9E 4,6-difluoro-N-(spiro[5.5]undecan-3-yl)-1h-indole-2-carboxamide PoSSuM
MHA (carbamoylmethyl-carboxymethyl-amino)-acetic acid PoSSuM
L6T Alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6AJJ   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN, HYDROLASE
Title : Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with ICA38
Release Data : 2018-12-26
Compound :
mol_id molecule chains synonym
1 Drug exporters of the RND superfamily-like protein,Endolysin A MmpL3 transporter,Lysis protein,Lysozyme,Muramidase
ec: 3.2.1.17
mutation: C54T, C97A
Source :
mol_id organism_scientific organism_common expression_system
1 Enterobacteria phage T4  (taxid:10665) Bacteriophage T4 Mycobacterium smegmatis str. MC2 155  (taxid:246196)
strain: ATCC 700084 / mc(2)155
gene: e, T4Tp126
Authors : Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Keywords : membrane protein, transporter, RND family, cell wall biosynthesis, drug target, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.7940 Å )
Citation :

Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.

Zhang, B.,Li, J.,Yang, X.  et al.
(2019)  Cell  176 : 636 - 648.e13

PubMed: 30682372
DOI: 10.1016/j.cell.2019.01.003

Reaction

Chain : A
UniProt : I7G2R2 (MMPL3_MYCS2)
Reaction : -
Chain : A
UniProt : D9IEF7 (D9IEF7_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 ARBA:ARBA00000632, HAMAP-Rule:MF_04110, RuleBase:RU003788
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