Het-PDB Navi2 (PDB: 6AFR)

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Ligands
Code	Name		Style	Show	Link
9E3	5-[(4-fluoranylimidazol-1-yl)methyl]quinolin-8-ol				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6AFR

Code :

6AFR PDBj RCSB PDB PDBe

Header :

Signaling protein/inhibitor

Title :

Crystal Structure of the first bromodomain of human BRD4 in complex with 5-((4-fluoro-1H-imidazol-1-yl)methyl)quinolin-8-ol

Release Data :

2018-12-12

Compound :

mol_id	molecule	chains	synonym
1	Bromodomain-containing protein 4	A	Protein HUNK1
	fragment: UNP residues 44-168

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli K-12 (taxid:83333)
	gene: BRD4, HUNK1 expression_system_strain: K-12

Authors :

Xing, J., Zhang, R.K., Zheng, M.Y., Luo, C., Jiang, X.R.

Keywords :

Brd4, epigenetic, SIGNALING PROTEIN-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.998 Å )

Citation :

Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors

Xing, J.,Zhang, R.,Jiang, X. et al.
(2018) Eur J Med Chem 163 : 281 - 294

PDB ID: 6AFR