Brand  (β version)

PDB ID: 6ACR

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Ligands
Code Name Style Show Link
9TO N-(4-methoxyphenyl)-4-[3-(pyridin-3-yl)-1h-pyrazol-4-yl]pyrimidin-2-amine PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 6ACR   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK-59638
Release Data : 2019-03-20
Compound :
mol_id molecule chains synonym
1 Activin receptor type-1 A,B Activin receptor type I,ACTR-I,Activin receptor-like kinase 2,ALK-2,Serine/threonine-protein kinase receptor R1,SKR1,TGF-B superfamily receptor type I,TSR-I
ec: 2.7.11.30
mutation: R206H
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: ACVR1, ACVRLK2
expression_system_common: Fall armyworm
expression_system_cell_line: SF9
expression_system_vector_type: Baculovirus
Authors : Sakai, N., Mishima-Tsumagari, C., Matsumoto, T., Shirouzu, M.
Keywords : Inhibitor, Complex, Kinase, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.01 Å )
Citation :

Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H).

Sekimata, K.,Sato, T.,Sakai, N.  et al.
(2019)  Chem. Pharm. Bull.  67 : 224 - 235

PubMed: 30828000
DOI: 10.1248/cpb.c18-00598

Reaction

Chain : A, B
UniProt : Q04771 (ACVR1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho- L-threonyl-[receptor-protein] 2.7.11.30 -
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ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L- seryl-[receptor-protein] 2.7.11.30 PubMed:9748228
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