Brand  (β version)

PDB ID: 6A1F

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Ligands
Code Name Style Show Link
9OF 8-methoxy-5,5-dimethyl-5,6-dihydrobenzo[H]quinazolin-4-amine PoSSuM
PGE Triethylene glycol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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PTR O-phosphotyrosine
Glycosylation
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Structure summary

Code : 6A1F   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of human DYRK1A in complex with compound 14
Release Data : 2018-10-03
Compound :
mol_id molecule chains synonym
1 Dual specificity tyrosine-phosphorylation-regulated kinase 1A A Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,hMNB
ec: 2.7.12.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: DYRK1A, DYRK, MNB, MNBH
expression_system_strain: BL21(DE3)
Authors : Baba, D., Hanzawa, H.
Keywords : DYRK1a, transferase
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

Discovery of DS42450411 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4-aminopyrimidine derivatives.

Fukuda, T.,Ishiyama, T.,Katagiri, T.  et al.
(2018)  Bioorg. Med. Chem. Lett.  28 : 3333 - 3337

PubMed: 30217414
DOI: 10.1016/j.bmcl.2018.09.010

Reaction

Chain : A
UniProt : Q13627 (DYR1A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.12.1 PubMed:20981014, PubMed:22998443, PubMed:23665168, PubMed:24239188, PubMed:30773093
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.12.1 PubMed:20981014, PubMed:22998443, PubMed:23665168, PubMed:24239188
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.12.1 PubMed:20981014, PubMed:22998443, PubMed:23665168, PubMed:24239188
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[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+) 2.7.11.23 PubMed:25620562
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