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Ligands
Code Name Style Show Link
CXS 3-cyclohexyl-1-propylsulfonic acid
FMT Formic acid
GOL Glycerol
HSE L-homoserine
NA Sodium ion
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate
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Code : 6A0S   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Homoserine dehydrogenase from Thermus thermophilus HB8 complexed with HSE and NADPH
Release Data : 2018-11-28
Compound :
mol_id molecule chains
1 Homoserine dehydrogenase B,A
ec: 1.1.1.3
Source :
mol_id organism_scientific expression_system
1 Thermus thermophilus HB8  (taxid:300852) Escherichia coli  (taxid:562)
strain: HB8
gene: TTHA0489
Authors : Akai, S., Ikushiro, H., Sawai, T., Yano, T., Kamiya, N., Miyahara, I.
Keywords : OXIDOREDUCTASE, nad-dependent, dehydrogenase
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

The crystal structure of homoserine dehydrogenase complexed with l-homoserine and NADPH in a closed form

Akai, S.,Ikushiro, H.,Sawai, T.  et al.
(2019)  J. Biochem.  165 : 185 - 195

PubMed: 30423116
DOI: 10.1093/jb/mvy094

Chain : B, A
UniProt : Q5SL04 (Q5SL04_THET8)
Reaction: EC: Evidence:
Physiological Direction:
L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH 1.1.1.3 ARBA:ARBA00001406
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L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH 1.1.1.3 RuleBase:RU000579
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