Brand  (β version)

PDB ID: 6YA6

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
0SX 8-chloro-2-[(2s)-pyrrolidin-2-yl][1]benzofuro[3,2-D]pyrimidin-4(3h)-one PoSSuM
BO3 Boric acid PoSSuM
CL Chloride ion PoSSuM
IMD Imidazole PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
SEP Phosphoserine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6YA6   PDBj   RCSB PDB   PDBe
Header : CELL CYCLE
Title : Minimal construct of Cdc7-Dbf4 bound to XL413
Release Data : 2020-05-27
Compound :
mol_id molecule chains synonym
1 Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase A huCdc7,huCdc7,huCdc7
ec: 2.7.11.1,2.7.11.1,2.7.11.1
mol_id molecule chains synonym
2 Protein DBF4 homolog A B Activator of S phase kinase,Chiffon homolog A,DBF4-type zinc finger-containing protein 1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CDC7, CDC7L1
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DBF4, ASK, DBF4A, ZDBF1
Authors : Dick, S.D., Cherepanov, P.
Keywords : kinase, cdc7, dbf4, cell cycle, bivalent substrate, transferase
Exp. method : X-RAY DIFFRACTION ( 1.44 Å )
Citation :

Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase.

Dick, S.D.,Federico, S.,Hughes, S.M.  et al.
(2020)  Structure  28 : 954 - 962.e4

PubMed: 32521228
DOI: 10.1016/j.str.2020.05.010

Reaction

Chain : A
UniProt : O00311 (CDC7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:27401717
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:27401717
left-to-right
Chain : B
UniProt : Q9UBU7 (DBF4A_HUMAN)
Reaction : -