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Ligands
Code Name Style Show Link
CH1 3'-deoxy-cytidine-5'-triphosphate
MG Magnesium ion
ZN Zinc ion
Non-standard Residues
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Glycosylation
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Code : 6WOY   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION/DNA/RNA
Title : Thermus thermophilus RNA polymerase initially transcribing complex with 3'dCTP
Release Data : 2020-06-10
Compound :
mol_id molecule chains synonym
1 DNA-directed RNA polymerase subunit alpha A,B RNAP subunit alpha,RNA polymerase subunit alpha,Transcriptase subunit alpha
ec: 2.7.7.6
mol_id molecule chains synonym
2 DNA-directed RNA polymerase subunit beta C RNAP subunit beta,RNA polymerase subunit beta,Transcriptase subunit beta
ec: 2.7.7.6
mol_id molecule chains synonym
3 DNA-directed RNA polymerase subunit beta' D RNAP subunit beta',RNA polymerase subunit beta',Transcriptase subunit beta'
ec: 2.7.7.6
mol_id molecule chains synonym
4 DNA-directed RNA polymerase subunit omega E RNAP omega subunit,RNA polymerase omega subunit,Transcriptase subunit omega
ec: 2.7.7.6
mol_id molecule chains
5 RNA polymerase sigma factor SigA F
mol_id molecule chains
6 DNA (5'-D(P*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*G)-3') G
mol_id molecule chains
7 DNA (25-MER) H
mol_id molecule chains
8 RNA (5'-R(*GP*CP*A)-3') I
Source :
mol_id organism_scientific
1 Thermus thermophilus  (taxid:274)
mol_id organism_scientific
2 Thermus thermophilus  (taxid:274)
mol_id organism_scientific
3 Thermus thermophilus  (taxid:274)
mol_id organism_scientific
4 Thermus thermophilus  (taxid:274)
mol_id organism_scientific
5 Thermus thermophilus  (taxid:274)
mol_id organism_scientific
6 Thermus thermophilus  (taxid:274)
synthetic: yes
mol_id organism_scientific
7 Thermus thermophilus  (taxid:274)
synthetic: yes
mol_id organism_scientific
8 Thermus thermophilus  (taxid:274)
synthetic: yes
Authors : Shin, Y., Murakami, K.S.
Keywords : Initially transcribing complex, TRANSCRIPTION, TRANSCRIPTION-DNA-RNA complex
Exp. method : X-RAY DIFFRACTION ( 3.00 Å )
Citation :

The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases.

Makinen, J.J.,Shin, Y.,Vieras, E.  et al.
(2021)  Nat Commun  12 : 796 - 796

PubMed: 33542236
DOI: 10.1038/s41467-021-21005-w

Chain : A, B
UniProt : Q9Z9H6 (RPOA_THETH)
Reaction: EC: Evidence:
Physiological Direction:
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.6 -
-
Chain : C
UniProt : Q8RQE9 (RPOB_THET8)
Reaction: EC: Evidence:
Physiological Direction:
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.6 HAMAP-Rule:MF_01321
-
Chain : D
UniProt : Q8RQE8 (RPOC_THET8)
Reaction: EC: Evidence:
Physiological Direction:
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.6 HAMAP-Rule:MF_01322
-
Chain : E
UniProt : A0A1J1EUF1 (A0A1J1EUF1_THETH)
Reaction: EC: Evidence:
Physiological Direction:
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.6 ARBA:ARBA00024550, HAMAP-Rule:MF_00366
-
Chain : F
UniProt : Q72L95 (SIGA_THET2)
Reaction : -