Het-PDB Navi2 (PDB: 6WO2)

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Ligands
Code	Name		Style	Show	Link
CA	Calcium ion				PoSSuM
IPA	Isopropyl alcohol				PoSSuM

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine
02K	1-aminocyclohexanecarboxylic acid

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
ACE	Acetyl group
U67	4-methylpentan-1-amine

Download interaction data: 6WO2

Code :

6WO2 PDBj RCSB PDB PDBe

Header :

PEPTIDE BINDING PROTEIN

Title :

Crystal Structure of the Grb2 SH2 Domain in Complex with a Tripeptide: Ac-pY-Ac6c-N-isohexyl

Release Data :

2020-09-02

Compound :

mol_id	molecule	chains	synonym
1	Growth factor receptor-bound protein 2	A,B	Adapter protein GRB2,Protein Ash,SH2/SH3 adapter GRB2
	fragment: SH2 Domain

mol_id	molecule	chains
2	ACE-PTR-02K-ASN-U67	C,D

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: GRB2, ASH expression_system_strain: SG13009 expression_system_vector_type: Plasmid expression_system_plasmid: PQE-60

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Martin, S.F., Clements, J.H.

Keywords :

Grb2 SH2 Ligand preorganization, PEPTIDE BINDING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.0000 Å )

Citation :

Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions.

Cramer, D.L.,Cheng, B.,Tian, J. et al.
(2020) Eur.J.Med.Chem. 208 : 112771 - 112771

PDB ID: 6WO2