Brand  (β version)

PDB ID: 6WHF

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
9EP (2r)-5-[(acetyloxy)methyl]-2-{(1r)-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-3,6-dihydro-2h-1,3-thiazine-4-carboxylic acid PoSSuM
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Structure summary

Code : 6WHF   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/INHIBITOR
Title : class C beta-lactamase from Escherichia coli in complex with cephalothin
Release Data : 2020-04-22
Compound :
mol_id molecule chains
1 Beta-lactamase A,B
ec: 3.5.2.6
other_details: class C beta-lactamase
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:1269009) Escherichia coli BL21(DE3)  (taxid:469008)
strain: A35218R
gene: bla(ampc-EC31), blaEC, AJ318_17250, AZZ83_002790, D7Y10_20755, D7Y10_27165, D9L99_20655, D9L99_27090, DJ487_18405, DW236_18485, ELT23_15185
Authors : Chang, C., Maltseva, N., Endres, M., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Keywords : class C beta-lactamase, Escherichia coli, cephalothin, structural genomic, CSGID, Structural Genomics, Center for Structural Genomics of Infectious Diseases, HYDROLASE, HYDROLASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.40 Å )
Citation :

class C beta-lactamase from Escherichia coli in complex with Cephalothin

Chang, C.,Maltseva, N.,Endres, M.  et al.
To Be Published 

Reaction

Chain : A, B
UniProt : Q104Z6 (Q104Z6_ECOLX)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 RuleBase:RU361140
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