Brand  (β version)

PDB ID: 6WBI

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Ligands
Code Name Style Show Link
CBO Carbenoxolone PoSSuM
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Glycosylation
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Structure summary

Code : 6WBI   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN
Title : Cryo-EM structure of human Pannexin 1 channel with its C-terminal tail cleaved by caspase-7, in complex with CBX
Release Data : 2020-06-03
Compound :
mol_id molecule chains
1 Pannexin-1 A,B,C,D,E,F,G
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: PANX1, MRS1, UNQ2529/PRO6028
expression_system_common: Human
Authors : Lu, W., Du, J., Ruan, Z.
Keywords : ion channel, TRANSPORT PROTEIN
Exp. method : ELECTRON MICROSCOPY ( 4.39 Å )
Citation :

Structures of human pannexin 1 reveal ion pathways and mechanism of gating.

Ruan, Z.,Orozco, I.J.,Du, J.  et al.
(2020)  Nature  584 : 646 - 651

PubMed: 32494015
DOI: 10.1038/s41586-020-2357-y

Reaction

Chain : A, B, C, D, E, F, G
UniProt : Q96RD7 (PANX1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
chloride(in) = chloride(out) - PubMed:32494015, PubMed:33947837
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iodide(out) = iodide(in) - PubMed:32494015
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ATP(in) = ATP(out) - UniProtKB:Q9JIP4
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K(+)(in) = K(+)(out) - PubMed:15304325, PubMed:33947837
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Ca(2+)(in) = Ca(2+)(out) - PubMed:16908669, PubMed:33947837
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Na(+)(in) = Na(+)(out) - PubMed:32494015
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nitrate(in) = nitrate(out) - UniProtKB:Q9JIP4
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L-aspartate(out) = L-aspartate(in) - UniProtKB:Q9JIP4
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L-glutamate(out) = L-glutamate(in) - UniProtKB:Q9JIP4
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D-gluconate(in) = D-gluconate(out) - UniProtKB:Q9JIP4
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[Caspase-activated pannexin-1]
spermidine(in) = spermidine(out) 		- PubMed:32238926
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[Caspase-activated pannexin-1]
ATP(in) = ATP(out) 		- PubMed:15304325, PubMed:20944749, PubMed:32238926, PubMed:32494015
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