Brand  (β version)

PDB ID: 6W4X

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
FEO Mu-oxo-diiron PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM
MG Magnesium ion PoSSuM
TTP Thymidine-5'-triphosphate PoSSuM
Non-standard Residues
Code Name Show
FY3 2,3,5-trifluoro-L-tyrosine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6W4X   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Holocomplex of E. coli class Ia ribonucleotide reductase with GDP and TTP
Release Data : 2020-04-08
Compound :
mol_id molecule chains synonym
1 Ribonucleoside-diphosphate reductase 1 subunit alpha A,B Protein B1,Ribonucleoside-diphosphate reductase 1 R1 subunit,Ribonucleotide reductase 1
ec: 1.17.4.1
mol_id molecule chains synonym
2 Ribonucleoside-diphosphate reductase 1 subunit beta C,D Protein B2,Protein R2,Ribonucleotide reductase 1
ec: 1.17.4.1
Source :
mol_id organism_scientific expression_system
1 Escherichia coli (strain K12)  (taxid:83333) Escherichia coli  (taxid:562)
strain: K12
gene: nrdA, dnaF, b2234, JW2228
mol_id organism_scientific expression_system
2 Escherichia coli (strain K12)  (taxid:83333) Escherichia coli  (taxid:562)
strain: K12
gene: nrdB, ftsB, b2235, JW2229
Authors : Kang, G., Taguchi, A., Stubbe, J., Drennan, C.
Keywords : complex, OXIDOREDUCTASE
Exp. method : ELECTRON MICROSCOPY ( 3.6 Å )
Citation :

Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex.

Kang, G.,Taguchi, A.T.,Stubbe, J.  et al.
(2020)  Science  368 : 424 - 427

PubMed: 32217749
DOI: 10.1126/science.aba6794

Reaction

Chain : A, B
UniProt : P00452 (RIR1_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'- diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'- diphosphate 1.17.4.1 -
-
Chain : C, D
UniProt : P69924 (RIR2_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'- diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'- diphosphate 1.17.4.1 PROSITE-ProRule:PRU10014
-