Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
ACT Acetate ion
CO6 Isobutyryl-coenzyme a
GOL Glycerol
SO4 Sulfate ion
UNX Unknown atom or ion
Modified Residues
Code Name Link
YCM S-(2-amino-2-oxoethyl)-L-cysteine
Code : 6VO5
Header : TRANSFERASE
Title : Crystal structure of Human histone acetytransferas 1 (HAT1) in complex with isobutryl-COA and K12A mutant variant of histone H4
Release Data : 2020-03-11
Compound :
mol_id molecule chains synonym
1 Histone acetyltransferase type B catalytic subunit A,B Histone acetyltransferase 1
ec: 2.3.1.48
mol_id molecule chains
2 Histone H4 C,D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: HAT1, KAT1
expression_system_variant: -pRARE2
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a-LIC
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
Authors : Halabelian, L., Zeng, H., Dong, A., Loppnau, P., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Keywords : HAT1, histone acetyltransferase 1, Isobutyryl-CoA, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.6000 Å )
Citation :

Crystal structure of Human histone acetytransferas 1 (HAT1) in complex with isobutryl-COA and K12A mutant variant of histone H4

Halabelian, L.,Zeng, H.,Dong, A.  et al.
to be published 

Chain : A, B
UniProt : O14929 (HAT1_HUMAN)
Reaction : Acetyl-CoA + [histone] = CoA + acetyl- [histone].
Chain : C, D
UniProt : P62805 (H4_HUMAN)
Reaction : -