Brand  (β version)

PDB ID: 6VMS

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Ligands
Code Name Style Show Link
08Y Bromoergocryptine PoSSuM
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Glycosylation
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Structure summary

Code : 6VMS   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane
Release Data : 2020-06-17
Compound :
mol_id molecule chains synonym
1 Guanine nucleotide-binding protein G(i) subunit alpha-1 A Adenylate cyclase-inhibiting G alpha protein
mol_id molecule chains synonym
2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 B Transducin beta chain 1
mol_id molecule chains synonym
3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 C G gamma-I
mol_id molecule chains
4 scFv16 E
mol_id molecule chains synonym
5 Endolysin,D(2) dopamine receptor,D(2) dopamine receptor R Lysis protein,Lysozyme,Muramidase,Dopamine D2 receptor,Dopamine D2 receptor
ec: 3.2.1.17
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Rat Spodoptera frugiperda  (taxid:7108)
gene: Gnai1, Gnai-1
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: GNB1
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: GNG2
mol_id organism_scientific organism_common expression_system
4 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
mol_id organism_scientific organism_common expression_system
5 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: DRD2
Authors : Yin, J., Chen, K.M., Clark, M.J., Hijazi, M., Kumari, P., Bai, X., Sunahara, R.K., Barth, P., Rosenbaum, D.M.
Keywords : Dopamine, Dopamine receptor, GPCR, G protein, Parkinson's disease, SIGNALING PROTEIN
Exp. method : ELECTRON MICROSCOPY ( 3.8 Å )
Citation :

Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane.

Yin, J.,Chen, K.M.,Clark, M.J.  et al.
(2020)  Nature  584 : 125 - 129

PubMed: 32528175
DOI: 10.1038/s41586-020-2379-5

Reaction

Chain : A
UniProt : P10824 (GNAI1_RAT)
Reaction : -
Chain : B
UniProt : P62873 (GBB1_HUMAN)
Reaction : -
Chain : C
UniProt : P59768 (GBG2_HUMAN)
Reaction : -
Chain : R
UniProt : D9IEF7 (D9IEF7_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 ARBA:ARBA00000632, HAMAP-Rule:MF_04110, RuleBase:RU003788
-
Chain : R
UniProt : P14416 (DRD2_HUMAN)
Reaction : -