Brand  (β version)

PDB ID: 6V8T

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Ligands
Code Name Style Show Link
C6V Lsz102 PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6V8T   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with LSZ102
Release Data : 2019-12-25
Compound :
mol_id molecule chains synonym
1 Estrogen receptor A,B ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ESR1, ESR, NR3A1
Authors : Fanning, S.W., Greene, G.L.
Keywords : Breast cancer, acquired drug resistance, hormone therapy, selective estrogen receptor degrader/downregulator, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.1000 Å )
Citation :

Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.

Hosfield, D.J.,Weber, S.,Li, N.S.  et al.
(2022)  Elife  11

PubMed: 35575456
DOI: 10.7554/eLife.72512

Reaction

Chain : A, B
UniProt : P03372 (ESR1_HUMAN)
Reaction : -