Het-PDB Navi2 (PDB: 6V7T)

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Ligands
Code	Name		Style	Show	Link
CAZ	Acylated ceftazidime				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6V7T

Code :

6V7T PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of CTX-M-14 E166A/D240G beta-lactamase in complex with ceftazidime

Release Data :

2020-04-22

Compound :

mol_id	molecule	chains
1	Beta-lactamase	A,B
	ec: 3.5.2.6 mutation: E166A, D240G

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli BL21(DE3) (taxid:469008)
	gene: blaCTX-M-14, beta-lactamase CTX-M-14, bla, bla CTX-M-14, bla-CTX-M-14a, blaCTX-M, blaCTX-M-14a, blaCTX-M-14b, blaCTX-M-14c, blaCTX-M-27b, blatoho-3, blaUOE-2, CTX-M-14, AM465_01285, AM465_06510, AM465_23360, APT94_14605, BEN53_26220, BET08_34355, BJJ90_27545, BK334_27290, BOH76_00730, BON63_16015, BON66_01305, BON69_22545, BON71_04040, BON75_10525, BON76_14325, BON81_01055, BON83_15455, BON86_08515, BON91_02075, BON92_04750, BON94_23850, BON95_01680, BON96_03940, BXT93_06855, C5N07_28500, C5P43_21980, CDL37_21060, CR538_26855, CRT46_23505, DW236_20870, EIA08_25160, EIA21_26975, ELT23_05930, ETN48_p0088, FNJ69_13810, FQR64_24895, FTV90_03295, pCT_085, pHK01_011, RCS103_P0010, RCS30_P0082, RCS56_P0085, RCS60_P0031, RCS63_P0006, RCS65_P0008, RCS66_P0053, SAMEA4362930_00013, SAMEA4370290_00046 expression_system_strain: BL21(DE3)

Authors :

Brown, C.A., Hu, L., Sankaran, B., Prasad, B.V.V., Palzkill, T.G.

Keywords :

drug resistance, protein evolution, conformational change, enzyme kinetics, enzyme catalysis, protein stability, protein-drug interaction, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.34 Å )

Citation :

Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.

Brown, C.A.,Hu, L.,Sun, Z. et al.
(2020) J.Biol.Chem. 295 : 7376 - 7390

PDB ID: 6V7T