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Ligands
Code Name Style Show Link
SO4 Sulfate ion
Non-standard Residues
Code Name Show
0EH (2r)-2-amino-2-methylnonanoic acid
MK8 2-methyl-L-norleucine
Glycosylation
Code Name Emphasize
Modification
Code Name Show
NH2 Amino group
Code : 6V4G   PDBj   RCSB PDB   PDBe
Header : APOPTOSIS
Title : Crystal Structure Analysis of Zebra fish MDMX
Release Data : 2020-04-22
Compound :
mol_id molecule chains synonym
1 Protein Mdm4 A Double minute 4 protein,Mdm2-like p53-binding protein,Protein Mdmx,p53-binding protein Mdm4
mutation: L46V, V95L
mol_id molecule chains
2 Stapled peptide QSQQTF(0EH)NLWRLE(MK8)QN(NH2) B
Source :
mol_id organism_scientific organism_common expression_system
1 Danio rerio  (taxid:7955) Zebrafish Escherichia coli  (taxid:562)
gene: mdm4, mdmx
mol_id organism_scientific
2 Homo sapiens  (taxid:9606)
synthetic: yes
Authors : Seo, H.-S., Dhe-Paganon, S.
Keywords : apoptosis, p53 binding
Exp. method : X-RAY DIFFRACTION ( 1.2500 Å )
Citation :

Identification of a Structural Determinant for Selective Targeting of HDMX.

Ben-Nun, Y.,Seo, H.S.,Harvey, E.P.  et al.
(2020)  Structure  28 : 847 - 857.e5

PubMed: 32359398
DOI: 10.1016/j.str.2020.04.011

Chain : A
UniProt : Q7ZUW7 (MDM4_DANRE)
Reaction : -